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A new “atlas” of bacterial life on and within the human body has uncovered the fact that your palms, feet and forearms are a veritable United Nations of germs.

The scientists, using sophisticated gene-sequencing technologies, pinpointed specific bacterial types and where they like to thrive on and within the body. They found a wide variability of bacteria, depending on the spot on the body. They also found that bacterial colonies differed person to person, with each individual carrying his or her own “personalized” assortment of microorganisms.

“We’ve always known that there are microbes on us and in us,” said study author Noah Fierer, an assistant professor of microbial ecology at the University of Colorado at Boulder. “But we weren’t always able to isolate them and differentiate them from each other. With these new techniques, we can.”

“Each of us is really an archipelago of distinct habitats, at least as far as bacteria are concerned,” added senior study author Robert Knight, an assistant professor of chemistry and biochemistry and computer science at the University of Colorado. “It’s truly amazing how different the sites within the same body are, and how different the corresponding sites on different people are.”

The team’s work is being published Nov. 5 in the online version of Science. The study builds on earlier research, including a 2008 study that found that women had a greater diversity of bacteria on their palms than men.

The mapping project focused on seven to nine men and women, who were examined four times each over a three-month period. Researchers swabbed 27 different sites, searching for bacteria in virtually every nook and cranny, from hair to ear wax, mouth to nostril and trunk and legs.

So, where are the most popular places for bacteria to hang out? They seem to like the gut (no surprise there), forearms, palms, index fingers, the backs of the knees and soles of the feet, according to the study. At least that is where some of the most diverse and thriving colonies take root.

Some bacterial communities appeared to strongly prefer one body spot over another. For example, when the scientists transplanted microbial groupings from the forearm to the forehead, the germs failed to thrive. But doing the reverse — transplanting communities from forehead to forearm — didn’t seem to impede bacterial growth.

Researchers focused on bacterial diversity rather than bacterial quantity. There are thousands of bacterial types, but certain ones seemed prominent in the study, said Fierer. Four bacterial groups stood out — Actinobacteria, Firmicutes, Proteobacteria and Bacteroidetes — and they were relatively stable over time. Individual bacterial types included the Streptococcus and Staphylococcus bacteria.

In some ways, the mapping efforts spurs more questions than it answers. Researchers are not sure why the forearms and other body parts attract so much microbial diversity. Also, it is not clear whether the different strains compete with each other or live in a kind of bacterial harmony.

Researchers also want to know whether people are born with these bacterial colonies or develop them after birth, through external contact with their mothers and during the delivery process. Even more fascinating is why each person has his or her own blend of bacteria — much like a fingerprint. Perhaps diet, climate, locale or a combination of variables are responsible for each person’s unique bacterial make-up, said Fierer.

Most important, researchers want to know how the colonies impact health and whether they can be harnessed in some way to treat disease. In the future, for example, microbial mapping could lead to routine screening of patients as a way to record a baseline of their normal microbial communities. Any later deviation could be a sign of disease.

“Our ultimate goal is to devise strategies for personalized medicine, based not on the human genome, where we are all 99.9 percent identical, but on the human microbiome, where we are 80 to 90 percent different from one another,” added Knight.

Women with atrial fibrillation are significantly more likely to have a stroke or die than are men with the heart condition, a new study has found.

Despite this, the study suggests, women with the condition receive less medical attention than men.

Atrial fibrillation occurs when the two small upper chambers of the heart, the atria, quiver rather than beat effectively. This can lead to pooling and clotting of blood. If a clot travels from the atria to an artery in the brain, it can cause a stroke.

Rush University Medical Center researchers reviewed past studies and medical literature and found that women with atrial fibrillation are more likely than men to experience symptomatic attacks and have recurrences, and that women have significantly higher heart rates during atrial fibrillation, which increases the risk for stroke.

“Stroke is one of the most devastating results of cardiovascular disease, and atrial fibrillation increases the risk of stroke,” the lead investigator, Dr. Annabelle Volgman, medical director of the Heart Center for Women at Rush University Medical Center, said in a news release from the hospital. “Women are at higher risk of atrial fibrillation-related stroke than men and are more likely to live with stroke-related disability, which can significantly lower quality of life.”

Volgman and her fellow researchers reviewed 20 years of studies that examined gender differences in atrial fibrillation and “were able to determine the most rational, safe and effective gender-specific approach to therapy for women.”

For starters, prevention therapies should be emphasized, the researchers said, as should treatments to ensure safe management once the condition is diagnosed.

Their findings and recommendations related to gender differences included:
Women are not prescribed blood thinners as often as men, resulting in a higher incidence of the formation of clots that break loose and block other vessels. The risk/benefit ratio should be assessed individually for each woman.
Women have a greater risk of bleeding from anticoagulation therapy, so this treatment must be monitored carefully.
Closely monitor women being treated with antiarrhythmic drugs because they have a higher risk for life-threatening arrhythmias and slow heart rates requiring permanent pacing.
Women’s hormonal fluctuations can cause more life-threatening arrhythmias.
Monitor women’s potassium levels in the blood because they have a higher risk of low levels, which boost the risk for drug-related arrhythmias.
Because women have a higher sensitivity to such therapies as statins and vasodilators, liver and kidney function should be closely watched.
Women are referred less often or later for non-drug treatments such as pacemaker implantation or ablation. Ablative therapy should remain an option for symptomatic women because they have success rates similar to those of men.

The study also found that, in general, women with atrial fibrillation have a lower quality of life than men with the disease. But the researchers said that careful assessment and relief of symptoms, and adequate control of heart rate or rhythm can make things better.

“For women with atrial fibrillation, these gender differences should always be kept in mind to help prevent strokes and heart failure and improve their quality of life,” Volgman said.